Cardiovascular Injury, Repair & Regeneration (CaIRRe)

The CaIRRe theme in CVS brings together basic and clinical scientists to study Vascular function, injury and remodelling, Vascular Regeneration, Myocardial injury, repair and remodelling, and Myocardial regeneration.  Studies range from transcriptional analysis, stem cells and cellular communication, through in vivo experimental models of CV disease, including model organisms; to clinical translation, big data, epidemiology and clinical trials, and include cutting edge clinical and pre-clinical structural, functional and molecular in vivo imaging (in collaboration with CINEMA theme).

Metabolism, Obesity, and Diabetes

Lipid droplets in zebrafish

The Metabolism Obesity and Diabetes Theme at the Centre for Cardiovascular Sciences, QMRI brings together clinical and basic scientists with an interest in the physiology and pathophysiology of metabolic processes relevant to obesity, diabetes and cardiovascular disease. Our research covers developmental processes (e.g. in utero effects), genetics and epigenetics, mature cell function and pathogenesis (e.g. Inflammation), through to regeneration and transplant of organs that are central to metabolic homeostasis: adipose (visceral, marrow, brown), liver, heart, kidney, pancreatic islets and lymphoid tissue. The aim of the Metabolism Obesity and Diabetes Theme is to act as a forum for cross-disciplinary collaborations aimed at understanding and ultimately treating cardiometabolic diseases.

Cardio-metabolic Imaging

Non-invasive imaging techniques have revolutionised the ability to determine primary causes of cardiac, vascular and metabolic disease as well as the efficacy of potential therapies. The Cardio-metabolic Imaging theme is a PI lead group of physicists, engineers, clinicians and biologists who work together, as well as across CVS themes and external collaborations, to generate disease modelling and novel imaging techniques that will ultimately improve diagnosis and future therapies.

Hypertension & Renal Theme (HART)

High blood pressure is the major risk factor driving the global crisis of non-communicable disease, chiefly Cardiovascular Disease and Chronic Kidney Disease. These diseases reduce the quality of life for millions of people and the medical care is costly. Cardiovascular disease is the leading cause of death worldwide: patients with kidney disease are more likely to die of a cardiovascular complication than progress to renal failure. The Hypertension and Renal theme focusses research on these global health challenges.

HART is a cohesive critical mass of hypertension and renal scientists with >£10 million of current funding from major UK funding bodies & industry partners. Publishing 250 papers in the past 5 years, our prize-winning scientists have a world-leading track record of discovery biology translating through to guideline-changing clinical trials. Our strategy is to identify important molecular mechanisms, focussing on the interactions between hypertension, inflammation & vascular dysfunction that will eventually lead to fibrosis, a common endpoint of all chronic diseases. This focus on early event biology, coupled with enhanced clinical biomarker discovery, makes preventative intervention a realistic outcome. Parallel interrogation of kidney development using bioengineering makes repair and regeneration a viable alternative for CKD.