Understanding the Pathogenesis of Type 1 Diabetes

Understanding the Pathogenesis of Type 1 Diabetes

Image 1: Cells within islet visualised using HiVolution: super resolution live imaging with confocal microscope (Leica SP8 3D multi-colour gSTED). Cells stained with mitotracker green (490/516). Image - Professor Rory Duncan’s laboratory, Heriot Watt University by Medical Research Scotland funded PhD student Dr Garcia Burgos.

Using human islets transplanted into immunodeficient mice under different glycaemic conditions, we aim to study the secretion of hormones from human islets with high resolution microscopy.


Principal Investigators: Rory McCrimmon - University of Dundee, Rory Duncan - Heriot Watt University and Shareen Forbes - University of Edinburgh

Collaborators: Scottish National Blood Transfusion Service, Helmsley Foundation, nPOD

Team members involved in this programme: Gary Borthwick, Adrian Garcia Burgos, Alison McNeilly, Paul Borgoyne, June Noble

Funding: Helmsley Foundation