Diseases We Study

Diseases We Study

Metabolic Disease

Image of atherosclerotic lesions

Obesity is a major health problem with approximately one in five people classed as obese and a further quarter of us classed as overweight. Obesity substantially increases the risk of developing metabolic diseases such as type two diabetes and high cholesterol and substantially increases the risk of having a heart attack or stroke (cardiovascular disease). At present, there are very few treatments for obesity and it is not fully understood how obesity causes metabolic disease.

Kidney disease

Kidney disease affects approximately 5% of the UK population and is a major risk factor for cardiovascular disease. Despite the best treatment currently available, some patients with kidney disease may progress to kidney failure and require dialysis therapy or a kidney transplant. Hence there is a need for further research to understand the factors that cause kidney disease and to use this information to develop new therapies to slow or prevent disease progression.

Cardiovascular disease

Cardiovascular disease, including both heart disease and stroke, is the leading cause of death and disability worldwide. This is not just a problem for the richest countries: it is now also a major issue in low- and middle-income nations. In the Centre for Cardiovascular Science, we study a range of strategies to improve diagnosis and treatment of cardiovascular disease. Some examples are highlighted below, and you can explore in more detail on our Research pages.