Cardiometabolic Imaging (CINEMA)

Cardiometabolic Imaging (CINEMA)

 

Non-invasive imaging techniques have revolutionised the ability to determine primary causes of cardiac, vascular and metabolic disease as well as the efficacy of potential therapies. The Cardiometabolic Imaging: New Methods and Applications (CINEMA) theme is a PI lead group of physicists, engineers, clinicians and biologists who work together, as well as across CVS themes and external collaborations, to generate disease modelling and novel imaging techniques that will ultimately improve diagnosis and future therapies.

The CINEMA theme members collaborate across the CVS research themes and beyond to develop and provide state-of-the are in vivo imaging and modelling to our users and collaborators.  Our members are currently pursuing the following research priorities:

  • (Injectable) Biomarker development
  • Hardware and software development
  • Image analysis, big data and modelling
  • In vivo imaging and modelling of humans and animals can provide important information on structure and function of different organs in a non invasive manner.

Under the umbrella of Edinburgh Imaging, many CVS members use the excellent preclinical (Edinburgh Preclinical Imaging) and clinical (CRIC - Edinburgh Imaging Facility QMRI and BRIC - Edinburgh Imaging Facility WGH) facilities to generate state-of the art imaging protocols to determine novel biomarkers and therapies for their respective fields.

Magnetic Resonance Imaging (MRI)

The Centre for Cardiovascular science has had a long tradition in innovation of cardiac imaging from Preclinical MRI informing clinical diagnostic techniques. These innovations have lead to major clinical trials (MA3RS study and EVOLVED TRIAL). Present preclinical MRI projects for clinical translation include are on novel manganese-enhanced imaging of the myocardium, measuring fibrosis and adverse cardiac remodelling under pressure overload in the mouse and cardiac 23Na MRI imaging to identify viability of myocardium after cardiac infarction and multimodality imaging of myocardial infarction.

Further studies are investigating novel contrast agents in studies of Type 1 and Type 2 diabetes.

Positron Emission Tomography (PET)

CVS researchers lead a multicentre cohort study determine if 18F-PET imaging can identify high-risk vulnerable coronary artery plaques (SCOT-HEART trial). The Saltire 2 project will use PET/CT imaging to assess the potential for new treatments to halt the progression of aortic stenosis and reduce the need for valve replacement surgery. The preclinical PET researchers are developing new PET ligands: 18F-LW223 is a ligand that will identify cardiovascular inflammatory disease, improving on present ligands which are susceptible to polymorphisms (Detection of cardiovascular inflammation using PET) and an 18F-Proline probe for the identification of cardiac fibrosis activity (PET imaging biomarkers of fibrosis).

Standardisation of preclinical PET protocols across PET scanners and PET facilities is essential to enable comparable data for crucial translation of data to human imaging. A cross country, multicentre analysis of PET/CT scanners and protocols is being carried out to achieve standardised protocols.

High Definition Ultrasound

High definition ultrasound is used to assess functional and structural outcomes from fetus through to adult. Present ongoing projects will identify the consequences of high and low glucocorticoid exposure on placental development and haemodynamic function. These studies will inform on the functional changes in feto-placental vasculature impacting on heart development and determine mechanisms whereby prenatal glucocorticoid exposure can underpin neonatal and adult cardiometabolic health. 

Research in a Nutshell Videos:

Prof Megan Holmes

Prof David Newby

Prof Carmel Moran

Dr Scott Semple

Dr Adriana Tavares

Related researchers:

Megan Holmes (Scientist Lead), David Newby (Clinical Lead), Carmel MoranScott SemplePeter HoskinsMaurits JansenAdriana Tavares (ECR)

 

CINEMA Twitter: @EdinUniCINEMA