Metabolism, Obesity, and Diabetes (MOD)

Metabolism, Obesity, and Diabetes (MOD)

Lipid droplets in zebrafish

Image of adipose in zebrafish: Minchin laboratory


The Metabolism Obesity and Diabetes Theme (MOD) at the Centre for Cardiovascular Sciences, QMRI brings together clinical and basic scientists with an interest in the physiology and pathophysiology of metabolic processes relevant to obesity, diabetes and cardiovascular disease. 

Our research covers developmental processes (e.g. in utero effects; Rebecca ReynoldsMandy DrakeKaren Chapmanadipose cell lineage and heterogeneityYou-Ying Chau), genetics – including utilisation of model organisms (Nik MortonRob SempleMargarete HeckJames Minchin), epigenetics and gene regulation (Mandy Drake, Matt Brook), mature cell function and pathogenesis (e.g. insulin resistanceRob Semple; insulin secretion, Shareen ForbesinflammationCecile BenezechhypoxiaZoi Michailidou and steroid metabolismRuth AndrewRuth MorganMark Nixon), through to regeneration and transplant of organs (Shareen Forbes) that are central to metabolic homeostasis.

We have a particular interest in adipose tissue distribution and function (visceral/subcutaneous; Rob SempleJames Minchin, You-Ying ChauRuth MorganMark Nixon; marrow; Will Cawthorn, brown/beige; Roland StimsonZoi Michailidou). We also study integrated metabolism of the liver, heart (Karen Chapman), kidney, muscle (Roland Stimson), pancreatic islets (Shareen ForbesNik Morton) and lymphoid tissue (Cecile Benezech).

The aim of the Metabolism Obesity and Diabetes Theme is to act as a forum for cross-disciplinary collaborations aimed at understanding and ultimately treating cardiometabolic diseases.



Principal Investigators and Early Career Fellows:

Rebecca ReynoldsMandy DrakeKaren ChapmanYou-Ying ChauNik MortonRob SempleMargarete HeckJames Minchin, Matt Brook, Shareen ForbesCecile BenezechZoi MichailidouRuth AndrewRuth MorganMark NixonWill Cawthorn, Roland StimsonLaura Denby, Sari Pennings, Tim Aitman, Phil Coan, Joyce Yau, and Scott Webster