Kidney disease affects approximately 5% of the UK population and is a major risk factor for cardiovascular disease. Despite the best treatment currently available, some patients with kidney disease may progress to kidney failure and require dialysis therapy or a kidney transplant. Hence there is a need for further research to understand the factors that cause kidney disease and to use this information to develop new therapies to slow or prevent disease progression.
In the Centre for Cardiovascular Science, we study a range of kidney diseases including damage due to diabetes and high blood pressure (hypertension), inflammatory diseases of blood vessels (vasculitis) that cause damage to many organs including the kidneys and kidney injury due to drugs and poisons. We are investigating how these diseases promote inflammation and scarring in the kidneys, which may ultimately lead to kidney failure. In addition, we are attempting to understand why patients with kidney disease are at increased risk of cardiovascular disease.